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These include producing short-chain fatty acids (SCFAs) such as butyrate and propionate, which can stimulate L-cell activity and enhance GLP-1 secretion

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Evidence for this comes from the Otsuka Long Evans Tokushima Fatty rat which has a null mutation in the CCK-1 receptor

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When truncated by DPP-4, NPY has a half-life of 2 to 3 min, after which it loses the ability to bind to the Y1R [76]

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